We also used a zebrafish embryo xenograft model to validate the synergistic interactions. Methods: The MGC803 cell viability was determined by Cell Counting Kit-8 assay, and the interactions between apatinib and conventional cytotoxic agents revealed by combination index values were calculated using Calcusyn 2.0 software. Hence, we aimed to assess the efficacy and safety of apatinib combined with chemotherapy in vivo and in vitro. However, its impact on the chemosensitivity of GC remains to be determined. Apatinib, a small-molecule tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor-2, improves outcomes in GC patients as a third-line treatment. Background and aim: Paclitaxel (PTX) plus 5-fluorouracil (5-Fu) has become the standard chemotherapy for advanced gastric cancer (GC).
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